Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 1.365


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX1hg19_v1_chr10_+_102891060_1028912970.217.4e-02Click!
TLX3hg19_v1_chr5_+_170736287_1707363690.181.3e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_151345156 22.159 NM_003944
SELENBP1
selenium binding protein 1
chr17_-_27948345 17.853 NM_032854
CORO6
coronin 6
chrX_+_102631408 16.117 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr3_-_139396773 12.617 NM_001200047
NM_178177
NMNAT3

nicotinamide nucleotide adenylyltransferase 3

chrX_+_102631267 12.443 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr1_-_39407449 12.155 NM_017821
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr10_+_17271341 9.961 VIM
vimentin
chr10_+_17271276 9.698 VIM
vimentin
chr10_+_17271277 9.638 VIM
vimentin
chr10_+_17271302 9.554 VIM
vimentin
chr10_+_17270469 9.446 VIM
vimentin
chr14_+_24867926 9.206 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr10_-_17271955 8.247


chr9_+_90112754 8.071 NM_004938
DAPK1
death-associated protein kinase 1
chr1_-_41950296 8.023 NM_001956
EDN2
endothelin 2
chr5_-_111092865 7.704 C5orf13
chromosome 5 open reading frame 13
chr5_-_111093251 7.553 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr7_-_16844606 7.162 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr14_+_85996512 6.925 FLRT2
fibronectin leucine rich transmembrane protein 2
chr12_+_111471827 6.785 NM_015267
CUX2
cut-like homeobox 2
chr5_-_111092918 6.382 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr16_+_226678 6.328 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr10_+_17271859 6.317 VIM
vimentin
chr16_+_222845 6.280 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr14_+_85996454 6.273 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr16_-_19896105 6.208 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr21_+_46875402 5.875 NM_030582
COL18A1
collagen, type XVIII, alpha 1
chr5_-_111093030 5.721 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr19_-_7698569 5.667 NM_174895
PCP2
Purkinje cell protein 2
chr17_+_38599651 5.656 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr10_+_17271956 5.565 VIM
vimentin
chr19_-_1812198 5.504 NM_001178002
NM_138813
ATP8B3

ATPase, aminophospholipid transporter, class I, type 8B, member 3

chr1_-_205391180 5.258 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr21_+_47531369 5.186 COL6A2
collagen, type VI, alpha 2
chr7_+_1127722 4.784 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr14_+_73704204 4.716 NM_173462
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr10_+_22540986 4.690 LOC100130992
uncharacterized LOC100130992
chr9_+_35673852 4.688 NM_001216
CA9
carbonic anhydrase IX
chr1_-_109399705 4.479 NM_152763
AKNAD1
AKNA domain containing 1
chr1_-_16539103 4.391 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr6_-_31550065 4.354 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr20_-_44519629 4.320 NM_080749
NEURL2
neuralized homolog 2 (Drosophila)
chr10_-_100174891 4.264 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr21_-_28217692 4.232 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr17_+_77030471 4.231 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr17_-_4463816 4.172 NM_001122890
NM_153338
GGT6

gamma-glutamyltransferase 6

chr3_+_46742822 4.139 NM_147196
TMIE
transmembrane inner ear
chr7_+_22766765 4.106 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr6_+_135502521 3.906 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr12_-_8815370 3.792 NM_003480
MFAP5
microfibrillar associated protein 5
chr19_+_4304590 3.789 NM_024333
FSD1
fibronectin type III and SPRY domain containing 1
chr3_-_53880403 3.759 NM_018397
CHDH
choline dehydrogenase
chrX_-_128788913 3.704 NM_017413
APLN
apelin
chr6_+_132129154 3.663 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr1_+_116380404 3.646 NHLH2
nescient helix loop helix 2
chr2_-_216300444 3.481 FN1
fibronectin 1
chr1_+_152748847 3.404 NM_178354
LCE1F
late cornified envelope 1F
chr20_+_58251715 3.402 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr11_+_65268313 3.360 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr3_-_197300193 3.266 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr14_+_96858436 3.249 NM_152327
AK7
adenylate kinase 7
chr12_+_57522247 3.246 NM_002332
LRP1
low density lipoprotein receptor-related protein 1
chr3_-_48601200 3.156 NM_033199
UCN2
urocortin 2
chr21_-_28217272 3.123 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chrX_-_154114431 3.034 NM_019863
F8
coagulation factor VIII, procoagulant component
chr3_-_48700317 3.033 NM_001407
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr6_-_30043547 3.015 NM_170769
NM_025236
RNF39

ring finger protein 39

chr1_+_201979689 2.958 NM_001114309
NM_004433
ELF3

E74-like factor 3 (ets domain transcription factor, epithelial-specific )

chr12_+_57522429 2.905 LRP1
low density lipoprotein receptor-related protein 1
chr11_-_33913835 2.904 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_-_131347249 2.892 NM_001009185
NM_001205247
NM_015256
ACSL6


acyl-CoA synthetase long-chain family member 6


chr5_+_150020201 2.882 NM_001109974
NM_007286
SYNPO

synaptopodin

chr6_+_39760772 2.856 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr19_+_39279849 2.798 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr6_+_132129195 2.797 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr3_+_38032260 2.772 VILL
villin-like
chr22_+_41763299 2.752 NM_001145398
TEF
thyrotrophic embryonic factor
chr1_-_36565849 2.718 NM_005202
COL8A2
collagen, type VIII, alpha 2
chr9_-_98268866 2.684 PTCH1
patched 1
chr17_+_4854383 2.649 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr7_-_27187367 2.644 NM_024014
HOXA6
homeobox A6
chr19_+_15783827 2.586 NM_023944
CYP4F12
cytochrome P450, family 4, subfamily F, polypeptide 12
chr1_+_154377847 2.534 IL6R
interleukin 6 receptor
chr1_-_23810627 2.532 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chrX_-_133119475 2.523 GPC3
glypican 3
chr19_+_56879687 2.473 ZNF542
zinc finger protein 542
chr8_-_21988518 2.445 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr8_-_82395401 2.429 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr9_-_23821842 2.424 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_-_23810721 2.390 NM_001143778
NM_017707
ASAP3

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

chr6_+_150920998 2.371 NM_001029884
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr17_+_40439564 2.364 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chrX_-_154563735 2.362 NM_001289
CLIC2
chloride intracellular channel 2
chr1_+_154378044 2.362 IL6R
interleukin 6 receptor
chrX_-_153095746 2.332 PDZD4
PDZ domain containing 4
chr12_-_8815266 2.315 MFAP5
microfibrillar associated protein 5
chr12_-_8815479 2.311 MFAP5
microfibrillar associated protein 5
chr5_-_172198160 2.288 NM_004417
DUSP1
dual specificity phosphatase 1
chr19_-_41934634 2.270 NM_198540
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr9_-_23821808 2.259 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr15_-_40213087 2.217 NM_007223
GPR176
G protein-coupled receptor 176
chr19_-_39264144 2.201 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr19_+_36157714 2.195 NM_007000
UPK1A
uroplakin 1A
chr2_-_220083394 2.171 ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr9_-_35618300 2.156 NM_001782
CD72
CD72 molecule
chr9_+_116356199 2.123 NM_144489
RGS3
regulator of G-protein signaling 3
chr12_-_10282680 2.110 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr9_+_116356407 2.041 RGS3
regulator of G-protein signaling 3
chr10_+_45455149 2.007 NM_032023
RASSF4
Ras association (RalGDS/AF-6) domain family member 4
chr9_-_124262035 2.007 GGTA1P
glycoprotein, alpha-galactosyltransferase 1 pseudogene
chr16_-_4562979 1.959 C16orf5
chromosome 16 open reading frame 5
chr16_-_3422282 1.932 NM_001190476
MTRNR2L4
MT-RNR2-like 4
chr2_+_66662516 1.931 NM_002398
MEIS1
Meis homeobox 1
chr4_-_84256304 1.912 NM_001166498
NM_006665
HPSE

heparanase

chr12_-_27235454 1.897 NM_001080406
C12orf71
chromosome 12 open reading frame 71
chrX_-_153095996 1.888 NM_032512
PDZD4
PDZ domain containing 4
chr11_-_560706 1.887 NM_173573
C11orf35
chromosome 11 open reading frame 35
chr11_-_71752099 1.876 NUMA1
nuclear mitotic apparatus protein 1
chr1_+_1846265 1.873 NM_138705
CALML6
calmodulin-like 6
chr11_+_6260321 1.872 NM_001037329
CNGA4
cyclic nucleotide gated channel alpha 4
chr19_+_14551087 1.864 PKN1
protein kinase N1
chr1_+_201979747 1.852 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr6_-_31745048 1.850 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr2_+_66662692 1.840 MEIS1
Meis homeobox 1
chr19_+_14551080 1.829 NM_213560
PKN1
protein kinase N1
chr5_+_121465214 1.819 NM_207317
ZNF474
zinc finger protein 474
chr4_-_84255895 1.818 NM_001199830
HPSE
heparanase
chr17_-_74533623 1.813 NM_134268
CYGB
cytoglobin
chr7_+_75932865 1.799 HSPB1
heat shock 27kDa protein 1
chr1_-_247275527 1.766 NM_207401
C1orf229
chromosome 1 open reading frame 229
chr19_+_37959981 1.735 NM_144694
ZNF570
zinc finger protein 570
chr19_+_14551052 1.694 PKN1
protein kinase N1
chr4_+_86749045 1.693 ARHGAP24
Rho GTPase activating protein 24
chr3_+_100211408 1.693 NM_018004
TMEM45A
transmembrane protein 45A
chr19_-_35454952 1.683 NM_175872
ZNF792
zinc finger protein 792
chr2_+_128293312 1.682 NM_001080527
MYO7B
myosin VIIB
chr9_-_23821477 1.656 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chrX_-_133119624 1.654 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr22_+_33196801 1.644 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr19_+_49547101 1.636 NM_033043
CGB
CGB5
chorionic gonadotropin, beta polypeptide
chorionic gonadotropin, beta polypeptide 5
chrX_-_153095810 1.627 PDZD4
PDZ domain containing 4
chr7_+_75932992 1.590 HSPB1
heat shock 27kDa protein 1
chr17_-_56606534 1.581 SEPT4
septin 4
chr10_-_43187174 1.580


chr3_+_192959108 1.578 HRASLS
HRAS-like suppressor
chr16_-_28550324 1.573 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr6_-_119470336 1.568 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr9_+_74764266 1.561 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr2_-_172967234 1.554 NM_004405
DLX2
distal-less homeobox 2
chr19_-_35454867 1.553 ZNF792
zinc finger protein 792
chr5_+_148961035 1.553 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr10_+_104503740 1.553 C10orf26
chromosome 10 open reading frame 26
chr16_+_57662301 1.533 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr15_-_67814131 1.515 LOC100506686
uncharacterized LOC100506686
chr17_+_72439187 1.506 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr5_-_146460991 1.498 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr11_-_6440288 1.492 NM_001164
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr11_+_27062508 1.486 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr1_+_84767288 1.475 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr1_-_183387404 1.470


chr11_-_64764388 1.470 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr3_+_14989076 1.468 NM_003298
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr2_-_7005764 1.442 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr7_+_75931829 1.427 NM_001540
HSPB1
heat shock 27kDa protein 1
chr7_+_75931991 1.400 HSPB1
heat shock 27kDa protein 1
chr19_-_39523132 1.398 NM_178820
FBXO27
F-box protein 27
chr1_+_154377668 1.395 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr10_+_102758072 1.391 LZTS2
leucine zipper, putative tumor suppressor 2
chr14_-_22005035 1.389 NM_005407
SALL2
sal-like 2 (Drosophila)
chr3_-_12586962 1.381 NM_001195279
LOC100129480
uncharacterized LOC100129480
chr2_-_172967014 1.380 DLX2
distal-less homeobox 2
chr6_-_55443853 1.379 NM_001042406
NM_019036
HMGCLL1

3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1

chrX_+_49126299 1.365 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory subunit 3F

chr15_+_45422130 1.354 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr21_+_40823779 1.335 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chrX_+_17653412 1.330 NM_001136024
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr19_+_20011700 1.325 NM_031218
ZNF93
zinc finger protein 93
chr2_-_192711923 1.323 NM_004657
SDPR
serum deprivation response
chr9_-_113800243 1.319 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chrX_-_71351750 1.306 NM_001024455
RGAG4
retrotransposon gag domain containing 4
chr8_-_79717540 1.299 NM_000880
NM_001199886
NM_001199887
NM_001199888
IL7



interleukin 7



chr2_-_172967627 1.290 DLX2
distal-less homeobox 2
chr9_+_124086842 1.288 GSN
gelsolin
chr4_+_166794409 1.287 NM_001204760
NM_012464
TLL1

tolloid-like 1

chr4_-_84255999 1.283 HPSE
heparanase
chr13_+_43148182 1.280 NM_003701
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr1_+_153600859 1.273 NM_006271
S100A1
S100 calcium binding protein A1
chr10_+_104503711 1.273 C10orf26
chromosome 10 open reading frame 26
chr1_-_206137430 1.271 LOC100132966
uncharacterized LOC100132966
chr3_+_53880606 1.267 IL17RB
interleukin 17 receptor B
chr19_+_17579577 1.256 SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr1_+_79115476 1.254 NM_006417
IFI44
interferon-induced protein 44
chr16_+_23765947 1.253 NM_022097
CHP2
calcineurin B homologous protein 2
chr11_+_46722564 1.251 NM_001184751
ZNF408
zinc finger protein 408
chr6_+_29555682 1.246 NM_007160
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr2_+_228029280 1.241 NM_000091
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr17_+_79885567 1.238 LOC92659
uncharacterized LOC92659
chr4_-_84256012 1.238 NM_001098540
HPSE
heparanase
chr1_+_220701547 1.237 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr10_-_81708860 1.232 NM_003019
SFTPD
surfactant protein D

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.75 8.14e-03 GO:0048856 anatomical structure development
45.89 2.16e-02 GO:0002548 monocyte chemotaxis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.85 1.87e-05 GO:0044421 extracellular region part
2.17 3.04e-05 GO:0005576 extracellular region
4.50 1.48e-04 GO:0005578 proteinaceous extracellular matrix
3.82 1.12e-03 GO:0031012 extracellular matrix
2.59 6.82e-03 GO:0005615 extracellular space
5.69 2.88e-02 GO:0044420 extracellular matrix part
61.19 4.54e-02 GO:0005896 interleukin-6 receptor complex

Nothing significant found in function category.